The drive is 440 km against 362 km as the crow flies, which is the ordinary shape of a German motorway journey. That is 4h 24 in a car that waits for you rather than the other way round, at a fare quoted in full at booking.
The fare is fixed when you book, so a closed lane or a slow stretch costs you time and not money — there is no meter and no waiting charge. Pickup is any address in Düsseldorf: a home, a hotel, an office, a venue. Drop-off is the exact address in Nuremberg, not the nearest station to it. The route crosses from Nordrhein-Westfalen into Bayern; the price covers the whole of it including tolls. The same fixed-price arrangement covers Düsseldorf to Frankfurt am Main, a separate route with its own measured distance.
An executive saloon on a 4h 24 run is a quiet place to work: the same car the whole way, no changes, no platform, and a driver who takes the route. Longer bookings are usually made a day or more ahead, and the return leg can be fixed at the same time and the same price. Arriving by air instead? Düsseldorf Airport Transfers covers every destination we serve from the airport.
Counting the whole journey, not the fast part of it
A rail time on a corridor this long is quoted platform to platform, and that stretch is the part of the day that goes well. Around it sit a local leg to the Hauptbahnhof, a margin you set yourself because the next departure is not for an hour, a change on most pairs this far apart, and another local leg at the other end with whatever you are carrying. A car quotes the whole thing instead: 4h 24 from the address you give us to the address you give us, one vehicle, one driver, nothing in between that can be missed. That does not make it faster — over 440 km it usually is not, and the comparison above says so. It makes the total knowable before you leave, which is a different property and occasionally the one that decides the booking: an early meeting, a connection at the far end, or a group whose day cannot absorb a missed change.